The match, which kicks-off at 7.15pm, will see Pep Guardiola’s side try and progress to the final eight of the competition for the fourth consecutive season, with the Sky Blues getting back to winning ways in the league on Saturday - a 1-0 victory over Everton.
As for Peterborough, they were on the receiving end of a 3-0 defeat to Hull City on Saturday, their third league defeat in as many games.
The Posh’s form in the Championship has been poor with no wins in their last six matches, leaving them bottom of the second tier.
The sides head into the game 43 places apart in the English football pyramid, with City top of the Premier League, while Peterborough 24th in the Championship.
This will be only the second meeting between City and the Posh with the former beating the latter 1-0 in the same round of the FA Cup in 1981.
What’s the latest team news?
There was only one change made to the Sky Blues’ starting XI against Everton with John Stones replacing Kyle Walker at right-back.
Guardiola confirmed in his pre-match press conference on Monday that Oleks Zinchenko will start the FA Cup tie.
“Yeah, Absolutely [he is fine],” Guardiola informed the press when asking if the left-back is OK to play.
“I think it will be good for him and to show that the reason why he is here is because he is a magnificent player.”
The Spaniard added that Zack Steffen is the only member of his squad who won’t be in contention to start, leading to a dilemma as to who will start between the sticks.
“No. Some knocks, but today everyone trained,” Guardiola said.
“Zack Steffen - Not yet [will he be back]. He is still in the gym.
“[We will] Decide tomorrow with Xabi [goalkeeper coach Mancisidor] [on who will play in goal]. Tomorrow we’ll talk about that.”
City will likely start with a 4-3-3 formation, although Guardiola has opted to use a 4-2-2-2 shape at times this season.
Peterborough will be without Oliver Norburn (suspension), Callum Morton (cup-tied), Dan Butler (ankle) and Jack Taylor (hamstring), while Mark Beevers could return to the matchday squad on Saturday.
Is the match on TV?
The match will be shown live on ITV 1 with coverage of the game starting at 6.45pm. Alternatively you can stream the game via ITV HUB.
How can I watch highlights?
ITV will put highlights of the fixture on their YouTube channel, while both City and Peterborough will also have the best bits of the game on their websites a few hours after the match.