The Spaniard was signed by Sir Alex Ferguson in 2011 and made a huge 545 appearances for the Red Devils, winning the Premier League, two FA Cup trophies, two League Cup trophies and the Europa League.
It leaves a hole between the sticks that Erik ten Hag will have to remedy this summer but also marks the end of an era as the last of Sir Alex Ferguson's signings departs from the North West.
ManchesterWorld looks at the last 21 players brought to the club by the legendary Manchester and what they are getting up to now.
1. Zoran Tosic - January 2009
Zoran Tosic spent just a year and a half at Manchester United, where he spent more time on loan and with the reserves than the first team, and left in 2010 - which he later said he regretted doing. Tosic is now 36 and plays for Super League Greece side Lamia.
2. Ritchie De Laet - January 2009
Ritchie De Laet never made his mark at Old Trafford but has enjoyed success since then. The 34-year-old won the Premier League with Leicester City and lifted the Belgian Pro League and Belgian Cup with Antwerp last season.
3. Antonio Valencia - July 2009
Manchester United legend Antonio Valencia retired from football in 2021. Since then, the 37-year-old founded AV25 Club Deportivo in Ecuador and has been seen bulking out in the gym.
4. Michael Owen - July 2009
England legend Michael Owen is regularly seen working as a pundit these days. He also appeared on The Masked Singer last year and owns Manor House Stables thanks to his love of horses.