Ralf Rangnick will be without Scott McTominay and Edinson Cavani for Manchester United’s Premier League clash against Watford on Saturday.
It means the interim manager will have to select a similar starting XI at Old Trafford to the one which began in Madrid on Wednesday night.
United came from behind to earn a 1-1 draw against Atletico, but for the second game in a row the Red Devils’ fortunes were impacted by substitutes coming off the bench.
It’s likely that at least one of those, Anthony Elanga, will earn a starting place when United take on Watford, following Rangnick’s positive comments in midweek.
“He is playing as though it is a dream come true, it is a joy and fun to watch him play, I wish a few other players would take him as an example and as a role model,” Rangnick said after the Champions League first leg.
“Football is an important sport, even more so for the supporters, and it is a ball game. This is what I wish us to do, especially in the second leg."
But attack is not the only area where Rangnick has a decision to make. He’ll almost certainly make a change in defence after Victor Lindelof’s odd selection at right-back on Wednesday, while the German may opt to rotate at left-back as well.
United’s midfield has looked more compact after the introduction of a defensive-minded player in the centre in each of the last two games, and that might also alter his thinking for Saturday’s encounter.
We’ve had a look at how we suspect Rangnick will line up at Old Trafford against the Hornets…
1. David De Gea
No goalkeeper has faced more shots in the league this season, but De Gea should hope for a more relaxed afternoon against the fourth-lowest scorers in the division.
2. Diogo Dalot
Not played in the last two but could come into the side with United expecting to see more of the ball at Old Trafford.
3. Raphael Varane
Was the Red Devils’ best defender in Madrid and has thrown off the illness that hampered him last week.
4. Harry Maguire
Struggled again against Atletico but has been undroppable this year for both Ole Gunnar Solskjaer and Ralf Rangnick. Maguire was sent off when the sides last met.