Matthijs de Ligt and Noussair Mazraoui could both make their Manchester United debuts in the Premier League opener against Fulham on Friday night.
Erik ten Hag's side kickstart the new top-flight season at Old Trafford and could have three new summer signings to showcase in the match, with Joshua Zirkzee also in line to be involved.
United will be hoping for a dream start to the new Premier League campaign and are on course to have De Ligt and Mazraoui available for selection after they underwent their respective medicals on Monday morning. They must be registered with the Premier League by midday on Thursday if they are to be available for selection against Fulham.
It means United could have a new-look defence to choose from on Friday night, with Diogo Dalot a contender to move to left-back, while De Ligt could partner Lisandro Martinez in central defence.
Here is what the United XI could look like with their new summer signings involved:
1. GK - Andre Onana
Onana will start for United in the opening fixture against Fulham. | Manchester United via Getty Images Photo: Manchester United via Getty Images
2. CB - Matthijs de Ligt
United have signed De Ligt to start and he could partner Lisandro Martinez while Leny Yoro is injured. | Getty Images Photo: Getty Images
3. CB - Lisandro Martinez
Martinez was much improved at centre-back against Man City and should start there. | Getty Images Photo: Getty Images
4. RB - Noussair Mazraoui
United have signed Mazraoui to replace Aaron Wan-Bissaka and he could be used right away. | Getty Images Photo: Getty Images