Matthijs de Ligt and Noussair Mazraoui could both make their Manchester United debuts in the Premier League opener against Fulham on Friday night.
Erik ten Hag's side kickstart the new top-flight season at Old Trafford and could have three new summer signings to showcase in the match, with Joshua Zirkzee also in line to be involved.
United will be hoping for a dream start to the new Premier League campaign and are on course to have De Ligt and Mazraoui available for selection after they underwent their respective medicals on Monday morning. They must be registered with the Premier League by midday on Thursday if they are to be available for selection against Fulham.
It means United could have a new-look defence to choose from on Friday night, with Diogo Dalot a contender to move to left-back, while De Ligt could partner Lisandro Martinez in central defence.
Here is what the United XI could look like with their new summer signings involved:
9. RW - Amad Diallo
Amad lacked end product against Man City but was a threat from the right wing at the weekend. | Getty Images Photo: Getty Images
10. LW - Alejandro Garnacho
You can't underestimate the ability of Garnacho and he has to start from the left wing. | Getty Images Photo: Getty Images
11. ST - Marcus Rashford
It might not be his favoured position but Rashford will likely start against Fulham with Joshua Zirkzee set for a bench role. | Getty Images Photo: Getty Images