The fixture was initially set to be played late last year, but was postponed following a COVID-19 outbreak within the Red Devils’ camp.
The stalemate against Southampton on Saturday left the Red Devils in fifth place, a point behind West Ham United with a game in hand.
And with no other top flight games scheduled for this midweek window, it’s a big chance for United to jump above the Hammers.
But with Arsenal just a point behind the Old Trafford outfit with two games in hand, the pressure remains on to ensure a top four finish.
What’s the latest team news?
Rangnick confirmed in his Monday press conference that Edinson Cavani will not return for the Brighton fixture.
The Uruguayan suffered a groin injury on Friday and missed the Southampton game.
Fred missed the weekend fixture after returning a positive test for COVID-19 but R
Nemanja Matic continues to suffer from a shin injury, while there will be some big decisions for Rangnick to make in midfield - especially when it comes to Paul Pogba.
While the Frenchman has started the last three games, he could be in need of a rest after recently returning from a long-term injury.
Harry Maguire could also see his place in the side under threat, with Victor Lindelof pushing for a start after the patchy form of his fellow centre-back.
Brighton are not expected to make many changes to their side, but could welcome back Yves Bissouma into the starting line-up after he returned from international duty.
Manchester United (4-3-3): De Gea; Dalot, Varane, Maguire, Shaw; McTominay, Pogba, Fernandes; Sancho, Ronaldo, Sancho.
Brighton & Hove Albion (3-5-2): Sanchez; Webster, Dunk, Veltman; Lallana, Bissouma, Gros, Lamptey, Moder; Welbeck, Maupay
Is Manchester United v Brighton on TV? Is there a live stream?
Manchester United’s clash with Brighton & Hove Albion will not be on TV.
While the original game was selected for broadcast on BT Sport, it will not be broadcast in the UK due to a clash with Champions League fixtures - which will also be broadcast on BT Sport.
That means there is no stream of the fixture for domestic supporters.
How can I watch highlights?
There are several ways to watch the highlights. The BT Sport YouTube channel will show all the main bits from the game, while both clubs’ websites will have highlights around two hours after the match concludes.
And follow ManchesterWorld for all the latest live from Old Trafford plus player ratings after the final whistle.