Ruben Amorim is expected to ring the changes when Manchester United make the short journey to face Man City in the Premier League on Sunday afternoon.
United bounced back from two defeats with victory over Viktoria Plzen in midweek, while City head into the match having won just one of their last 10 matches, including six defeats.
Amorim's side are arguably the favourites for the first Manchester derby of the season, though they still head into the clash eight points behind their noisy neighbours in the Premier League table.
United are set to only be without Luke Shaw for the match, with Amorim set to rotate his side heavily from the team that won in the Europa League during midweek.
Here is how we think United should line up against Plzen:
1. Manchester United face Man City in the Premier League on Sunday afternoon
Manchester United face Man City in the Premier League on Sunday afternoon | line-up builder Photo: line-up builder
2. GK - Andre Onana
Onana made an inexcusable mistake in midweek but will keep his place in goal amid a lack of serious competition. | Manchester United via Getty Images
3. CB - Noussair Mazraoui
Mazraoui has been the best performer under Amorim and should start again in a right centre-back role. | Manchester United via Getty Images
4. CB - Leny Yoro
It would be a big call but Yoro was signed to start matches and this would be the ultimate test in a United shirt. | Getty Images