Edinson Cavani is out of contract at the end of the season, while there have been rumours that 37-year-old Cristiano Ronaldo could already be on his way out of Old Trafford.
Despite becoming a fan favourite since his arrival in 2020, Cavani has struggled with injuries this season and has made just six league starts - making it increasingly unlikely that the Red Devils will offer him a new deal.
If the duo are to leave the club then United will be in desperate need of a new striker, with Rangnick already addressing their need for more goals.
Here are four young forwards that could replace Cavani and Ronaldo this summer...
The most obvious replacement is Borussia Dortmund’s Erling Haaland, who has long been linked with a move to the Premier League.
The 21-year-old has scored an impressive 16 goals in 14 league matches this season and has become of one of the world’s best at a very young age.
Haaland has attracted interest from a number of top clubs due to his reported £63m release clause - a bargain for a world-class attacker.
Alexsandar Isak has been linked with numerous clubs and Arsenal were most recently reported to be keen on bringing the striker to the Premier League last month.
The 22-year-old scored 17 goals in 34 league appearances for Real Sociedad last season and also impressed for Sweden during last year’s Euro 2020 tournament.
However, it is thought that the Spanish side won’t sell Isak for less than £75m - a price tag that the Gunners couldn’t afford.
Joao Felix has previously been linked with a move to England following his underwhelming transfer to Atletico Madrid.
The Portugal international was unstoppable for Benfica before his £113m switch to the Spaish giants, however he has failed to replicate that form in La Liga.
Felix evidently has a lot of potential and is still very young, however it is unclear how much Atletico would ask for the attacker given the hefty price they paid for him.
Jonathan David has scored almost 50 goals since his arrival at Lille in August 2020 and played a vital role as the French club won their the title last season.
United were reportedly interested in signing the 22-year-old prior to his move to Ligue 1, but he opted to join Lille in favour of playing time.
It is unknown how much a summer move for the Canadian would cost the Red Devils, however The Guardian reported in November that Lille could ask for as little as £25 million for his services due to their financial problems.