The Red Devils picked up their first win of the season with an impressive 2-1 victory over bitter rivals Liverpool on Monday evening.
That result was enough to lift Erik ten Hag’s side up to 14th in the table following an uncharacteristic stint in the relegation zone.
For their part, Southampton also secured a first win of the campaign in their last outing.
The Saints came from behind to pile further misery on struggling Leicester City in a 2-1 win at the King Power Stadium, with Che Adams on hand to score both goals.
But despite their spirited display last weekend, Sutton still believes that United will have too much for Ralph Hasenhuttl’s men.
Speaking to BBC Sport, he said: “I watched Southampton against Leicester last weekend. In the first half they had to weather a bit of pressure and then went behind to a James Maddison free-kick, but they responded brilliantly.
“They ended up deservedly winning the game after Che Adams came off the bench and scored twice, and this won’t be an easy one for Manchester United and boss Erik ten Hag.
“I didn’t see United turning up against Liverpool, I don’t think anybody did, but I think they can back up their victory and edge this one.”
Sutton has backed United to pick up a 2-1 win against the Saints.