Manchester United face rivals Leeds United, whilst Manchester City take on Tottenham Hotspur in the capital.
Both Manchester clubs have made big-money signings this summer in Jack Grealish and Jadon Sancho and will be hoping they can live up to their potential and grab plenty of goals and assists this season.
Here is how the bookies expect Sancho and Grealish’s chances at the golden boot to rank in comparison to the league’s biggest stars...
Here is how the bookies expect Sancho and Grealish’s chances at the golden boot to rank in comparison to the league’s biggest stars...