Manchester United face rivals Leeds United, whilst Manchester City take on Tottenham Hotspur in the capital.
Both Manchester clubs have made big-money signings this summer in Jack Grealish and Jadon Sancho and will be hoping they can live up to their potential and grab plenty of goals and assists this season.
Here is how the bookies expect Sancho and Grealish’s chances at the golden boot to rank in comparison to the league’s biggest stars...

9. Bruno Fernandes
BetVictor: 25/1 Sky Bet: 25/1 William Hill: 25/1 Photo: Michael Regan

10. Jamie Vardy
BetVictor: 25/1 Sky Bet: 28/1 William Hill: 28/1 Photo: Laurence Griffiths

11. Jadon Sancho
BetVictor: 66/1 Sky Bet: 50/1 William Hill: 50/1 Photo: Lars Baron

12. Jack Grealish
BetVictor: 100/1 Sky Bet: 100/1 William Hill: 80/1 Photo: Catherine Ivill
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