Once thriving industrial areas, they were densely populated with terraced housing for factory workers.
Hulme became known for its infamous 1960s crescents - modernist housing that later fell into disrepair.
Moss Side is a historically working class area which struggled with crime and poverty in late 20th Century as some of these photos reveal.
31 euphoric pics of Manchester's Hacienda nightclub when Noel Gallagher was a roadie before his Oasis days
1. Hulme and Moss Side past
Exteriors of some of the the notorious high density council housing at Hulme crescents in south west Manchester. The apartment blocks were built in the 1960's but quickly deterioted and the area became blighted by drug and gun crime. Gangs formed and parts of south Manchester became known as 'Gunchester'. Eventually the city council pulled down the apartment blocks and replaced them with small houses gardens and parks. This was 1987 | Getty Images
2. Hulme and Moss Side past
A block of 12M Jespersen flats under construction in Hulme, showing a wall panel with inset windows about to be hoisted into position, 1967 | Getty Images
3. Hulme and Moss Side past
A view over the construction site of three-storey flats in Hulme, built using the 12M Jespersen system, with the Manchester skyline in the distance including Manchester Central Railway Station, 1967 | Getty Images
4. Hulme and Moss Side past
A recently completed multi-storey block of 'Sectra' flats in Hulme, probably Hornchurch Court, with a family in the foreground buying from an ice cream van in 1965 | Getty Images